The Biological Behaviors of Rat Dermal Fibroblasts Can Be Inhibited by High Levels of MMP9

Figure 3

Scratch test of each group. (a) Control group 0 h (×40); (b) model group 0 h (×40); (c) tissue inhibitor of metalloproteinase 1 (TIMP1) group 0 h (×40); (d) control group 6 h (×40); (e) model group 6 h (×40); (f) TIMP1 group 6 h (×40); (g) histogram. The horizontal migration rate of fibroblasts in model group was lower than that in control group with the inhibition rate being 45.0%. After treatment with TIMP1, the horizontal migration rate increased compared with that in model group, but failed to recover to the level of control group. *𝑃<0.01 versus control group; ^#𝑃<0.01 versus model group. Data are mean ± SEM, 𝑛=5.

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