The Biological Behaviors of Rat Dermal Fibroblasts Can Be Inhibited by High Levels of MMP9

Table 1

Proliferation, viability, and collagen secretion of fibroblasts.

Group	S-phase cell ratio (%)	Proliferation index (%)	CCK-8 OD value	Hydroxyproline (pg/mL)
Control group	9.31±0.24	13.8±0.5	1.76±0.13	1126.4±62.7
Model group	6.54±0.29 *	11.3±0.6 *	1.35±0.12 *	352.8±60.6 *
TIMP1 group	7.75±0.27^*#	12.5±0.5^*§	1.64±0.14^#	828.6±58.9^*#

TIMP1: tissue inhibitor of metalloproteinase 1; *𝑃<0.01 versus control group; ^§𝑃<0.05; ^#𝑃<0.01 versus model group. Data are mean ± SEM, 𝑛=5.