Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats

Figure 2

The effect of saline, Pluronic F127, antioxidant saline, and antioxidant Pluronic F127 on wound closure in the normal rats (a) and diabetic rats (b). Full-thickness skin wounds of 1.0 × 1.0 cm were measured from the time of wounding until closures. The skin defect was compared to the initial wound size to determine wound closure rate by tracing the wound. (a) Closure of full-thickness skin wounds of normal rats showed no significant difference in the healing rate between four groups of treatment. (b) Wound closure of diabetic skin showed that the antioxidant sol-gel-treated wounds closed faster than the saline-, sol- and antioxidant saline-treated wounds on days 7 and 14. Data is expressed as mean ± SEM for three separate experiments, each in quadruplicate. *P < 0.05 when compared to saline control. (c) Representative pictures of skin wounds in group saline (a), Pluronic F127 (b), antioxidant saline (c), and antioxidant sol-gel (d) at day 7.