Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats
Figure 5
Effect of vitamin C on dermal maturation in diabetic rat wounds. Sections stained with H & E are displayed in the saline control (a), Pluronic F127 sol (b), saline plus vitamin C (c), and Pluronic F127 plus vitamin C (d). Histological evaluation of the 14-day wounds by H & E stain demonstrated enhanced healing characteristics including wound of proliferation, remodeling, and maturation in the antioxidant saline (c) or antioxidant sol-treated wound (d). Saline (a) or Pluronic 127 treatment (b) did not show any marked healing responses in the diabetic wounds. This advancement correlates with the fibroblast infiltration into the wounded area which was scored based on their maturity from reactive to normal. The mean score of dermal maturation is displayed in (e). The degree of dermal maturation is demonstrated in an order of FC > SC > F > S 14 days after wounding (e). Data are expressed as mean ± SEM. *Four groups are significantly different but not significant between saline and F127; vitamin C in saline and vitamin C in PF127. S: saline control; F: Pluronic F127; SC: saline plus vitamin C; FC: Pluronic F127 plus vitamin C. Original magnifications taken at ×100.
