Circulating TGF-β1, Glycation, and Oxidation in Children with Diabetes Mellitus Type 1

Figure 1

Comparison of (a) AGEs, (b) AOPP, (c) LPO and (d) TGF-β1 levels in diabetic patients and controls. Levels of AGEs are significantly higher in patients with DM1 than in healthy control (AGEs in serum 67.9 (61.6; 76.4) versus 58.2 (52.0; 65.0) A.U., 𝑃<0.001*) (Figure 1(a)). Parameters of oxidative stress AOPP an LPO are significantly higher in patients with DM1 than in control (AOPP: 80.5 (44.9; 139.9) versus 51.5; 66.9) μmol/L, 𝑃<0.01*) (Figure 1(b)) (LPO: 119.0 (100.3; 156.3) versus 99.0 (67.0; 106.0) nmol/mL, 𝑃<0.01*) (Figure 1(c)). The level of serum TGF-β was significantly higher in diabetics in comparison with control (7.1 (3.6; 12.6) versus 1.6 (0.8; 3.9) ng/mL, 𝑃<0.01*) (Figure 1(d)). *-Mann Whitney test.

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