Impact of Maternal Diabetes on Epigenetic Modifications Leading to Diseases in the Offspring

Figure 1

Maternal hyperglycemia and hyperinsulinemia and, consequently, fetal hyperglycemia and hyperinsulinemia alter the function of every stage of fetal metabolism, including the hypothalamus, the pancreas, and adipose tissue. These metabolic disturbances pass through the offspring and, eventually, could increase cardiovascular risk for the maturing young adult.