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Experimental Diabetes Research
Volume 2012 (2012), Article ID 538474, 6 pages
doi:10.1155/2012/538474
Impact of Maternal Diabetes on Epigenetic Modifications Leading to Diseases in the Offspring
12nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, 11528 Athens, Greece
21st Department of Obstetrics and Gynecology, Alexandra Hospital, School of Medicine, University of Athens, 11528 Athens, Greece
3Neonatal Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, 11528 Athens, Greece
4Department of Obstetrics and Gynecology, School of Medicine, University of Thessaly, 41334 Larissa, Greece
53rd Department of Obstetrics and Gynecology, Attiko Hospital, University of Athens, 12462 Athens, Greece
Received 18 September 2012; Accepted 26 October 2012
Academic Editor: Aristidis Veves
Copyright © 2012 Nikolaos Vrachnis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- N. Vrachnis, P. Belitsos, S. Sifakis et al., “Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus,” International Journal of Endocrinology, vol. 2012, Article ID 549748, 12 pages, 2012. View at Publisher · View at Google Scholar
- N. Vitoratos, N. Vrachnis, G. Valsamakis, K. Panoulis, and G. Creatsas, “Perinatal mortality in diabetic pregnancy,” Annals of the New York Academy of Sciences, vol. 1205, pp. 94–98, 2010. View at Publisher · View at Google Scholar · View at Scopus
- N. Vrachnis, A. Augoulea, Z. Iliodromiti, I. Lambrinoudaki, S. Sifakis, and G. Creatsas, “Previous gestational diabetes mellitus and markers of cardiovascular risk,” International Journal of Endocrinology, vol. 2012, Article ID 458610, 6 pages, 2012. View at Publisher · View at Google Scholar
- D. Simmons, “Epidemiology of diabetes in pregnancy,” in Practical Management of Diabetes in Pregnancy, D. McCance and M. Maresh, Eds., Blackwell Publishing., London, UK, 2010.
- IADPSG Consensus Panel, “International association of diabetes and pregnancy study groups (IADPSG) recommendations on the diagnosis and classification of hyperglycemia in pregnancy,” Diabetes Care, vol. 33, no. 7, pp. 676–682, 2010. View at Publisher · View at Google Scholar
- F. Galtier, “Definition, epidemiology, risk factors,” Diabetes & Metabolism, vol. 36, no. 6, pp. 628–651, 2010. View at Scopus
- A. E. Evensen, “Update on gestational diabetes mellitus,” Primary Care, vol. 39, no. 1, pp. 83–94, 2012.
- M. Lampl and P. Jeanty, “Exposure to maternal diabetes is associated with altered fetal growth patterns: a hypothesis regarding metabolic allocation to growth under hyperglycemic-hypoxemic conditions,” American Journal of Human Biology, vol. 16, no. 3, pp. 237–263, 2004. View at Publisher · View at Google Scholar · View at Scopus
- T. Jansson, I. Cetin, T. L. Powell et al., “Placental transport and metabolism in fetal overgrowth—a workshop report,” Placenta, vol. 27, pp. 109–113, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. A. Ashworth, F. N. Leach, and R. D. Milner, “Development of insulin secretion in the human fetus,” Archives of Disease in Childhood, vol. 48, no. 2, pp. 151–152, 1973. View at Scopus
- P. M. Catalano, A. Thomas, L. Huston-Presley, and S. B. Amini, “Increased fetal adiposity: a very sensitive marker of abnormal in utero development,” American Journal of Obstetrics and Gynecology, vol. 189, no. 6, pp. 1698–1704, 2003. View at Publisher · View at Google Scholar · View at Scopus
- A. Ericsson, K. Säljö, E. Sjöstrand et al., “Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport,” Journal of Physiology, vol. 581, no. 3, pp. 1323–1332, 2007. View at Publisher · View at Google Scholar · View at Scopus
- D. J. Pettitt, W. C. Knowler, and P. H. Bennett, “Obesity in offspring of diabetic Pima Indian women despite normal birth weight,” Diabetes Care, vol. 10, no. 1, pp. 76–80, 1987. View at Scopus
- B. L. Silverman, T. Rizzo, O. C. Green et al., “Long-term prospective evaluation of offspring of diabetic mothers,” Diabetes, vol. 40, supplement 2, pp. 121–125, 1991. View at Scopus
- B. L. Silverman, B. E. Metzger, N. H. Cho, and C. A. Loeb, “Impaired glucose tolerance in adolescent offspring of diabetic mothers: relationship to fetal hyperinsulinism,” Diabetes Care, vol. 18, no. 5, pp. 611–617, 1995. View at Scopus
- A. Plagemann, T. Harder, R. Kohlhoff, W. Rohde, and G. Dörner, “Glucose tolerance and insulin secretion in children of mothers with pregestational IDDM or gestational diabetes,” Diabetologia, vol. 40, no. 9, pp. 1094–1100, 1997. View at Publisher · View at Google Scholar · View at Scopus
- D. Dabelea and D. J. Pettitt, “Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility,” Journal of Pediatric Endocrinology and Metabolism, vol. 14, no. 8, pp. 1085–1091, 2001. View at Scopus
- N. Halfon, P. A. Verhoef, and A. A. Kuo, “Childhood antecedents to adult cardiovascular disease,” Pediatrics in Review, vol. 33, no. 2, pp. 51–60, 2012.
- J. Rasanen and P. Kirkinen, “Growth and function of human fetal heart in normal, hypertensive and diabetic pregnancy,” Acta Obstetricia et Gynecologica Scandinavica, vol. 66, no. 4, pp. 349–353, 1987. View at Scopus
- J. C. Bunt, P. Antonio Tataranni, and A. D. Salbe, “Intrauterine exposure to diabetes is a determinant of hemoglobin A1c and systolic blood pressure in pima indian children,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3225–3229, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. Manderson, B. Mullan, C. Patterson, D. Hadden, A. Traub, and D. McCance, “Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy,” Diabetologia, vol. 45, no. 7, pp. 991–996, 2002. View at Publisher · View at Google Scholar · View at Scopus
- N. M. Mordwinkin, J. G. Ouzounian, L. Yedigarova, M. N. Montoro, S. G. Louie, and K. E. Rodgers, “Alteration of endothelial function markers in women with gestational diabetes and their fetuses,” Journal of Maternal-Fetal and Neonatal Medicine. In press. View at Publisher · View at Google Scholar
- L. Aerts and F. A. Van Assche, “Animal evidence for the transgenerational development of diabetes mellitus,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 5-6, pp. 894–903, 2006. View at Publisher · View at Google Scholar · View at Scopus
- R. J. Gill-Randall, D. Adams, R. L. Ollerton, and J. C. Alcolado, “Is human Type 2 diabetes maternally inherited? Insights from an animal model,” Diabetic Medicine, vol. 21, no. 7, pp. 759–762, 2004. View at Publisher · View at Google Scholar · View at Scopus
- D. J. Petitt, H. B. Baird, and K. A. Aleck, “Excessive obesity in offspring of Pima Indian women with diabetes during pregnancy,” The New England Journal of Medicine, vol. 308, no. 5, pp. 242–245, 1983. View at Scopus
- D. Dabelea, W. C. Knowler, and D. J. Pettitt, “Effect of diabetes in pregnancy on offspring: follow-up research in the Pima Indians,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 9, no. 1, pp. 83–88, 2000. View at Scopus
- T. Harder, K. Franke, R. Kohlhoff, and A. Plagemann, “Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type I,” Gynecologic and Obstetric Investigation, vol. 51, no. 3, pp. 160–164, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. McLean, D. Chipps, and N. W. Cheung, “Mother to child transmission of diabetes mellitus: does gestational diabetes program Type 2 diabetes in the next generation?” Diabetic Medicine, vol. 23, no. 11, pp. 1213–1215, 2006. View at Publisher · View at Google Scholar · View at Scopus
- D. Dabelea, R. L. Hanson, R. S. Lindsay et al., “Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a Study of Discordant Sibships,” Diabetes, vol. 49, no. 12, pp. 2208–2211, 2000. View at Scopus
- A. Stride, M. Shepherd, T. M. Frayling, M. P. Bulman, S. Ellard, and A. T. Hattersley, “Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1α gene mutation carriers,” Diabetes Care, vol. 25, no. 12, pp. 2287–2291, 2002. View at Publisher · View at Google Scholar · View at Scopus
- D. J. Pettitt and W. C. Knowler, “Long-term effects of the intrauterine environment, birth weight, and breast-feeding in Pima Indians,” Diabetes Care, vol. 21, supplement 2, pp. B138–B141, 1998. View at Scopus
- L. Marroquí, A. Gonzalez, P. Ñeco et al., “Role of leptin in the pancreatic β-cell: effects and signaling pathways,” Journal of Molecular Endocrinology, vol. 49, no. 1, pp. 9–17, 2012.
- J. B. Susa, J. M. Boylan, P. Sehgal, and R. Schwartz, “Persistence of impaired insulin secretion in infant rhesus monkeys that had been hyperinsulinemic in utero,” Journal of Clinical Endocrinology and Metabolism, vol. 75, no. 1, pp. 265–269, 1992. View at Publisher · View at Google Scholar · View at Scopus
- B. Persson, M. Westgren, G. Celsi, E. Nord, and E. Örtqvist, “Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers,” Hormone and Metabolic Research, vol. 31, no. 8, pp. 467–471, 1999. View at Scopus
- H. Christou, J. M. Connors, M. Ziotopoulou et al., “Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 2, pp. 935–938, 2001. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Atègbo, O. Grissa, A. Yessoufou et al., “Modulation of adipokines and cytokines in gestational diabetes and macrosomia,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 10, pp. 4137–4143, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Yessoufou and K. Moutairou, “Maternal diabetes in pregnancy: early and long-term outcomes on the offspring and the concept of ‘metabolic memory’,” Experimental Diabetes Research, vol. 2011, Article ID 218598, 12 pages, 2011.
- A. L. Fowden and D. J. Hill, “Intra-uterine programming of the endocrine pancreas,” British Medical Bulletin, vol. 60, pp. 123–142, 2001. View at Publisher · View at Google Scholar · View at Scopus
- E. Pinter, J. Haigh, A. Nagy, and J. A. Madri, “Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation,” American Journal of Pathology, vol. 158, no. 4, pp. 1199–1206, 2001. View at Scopus