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Experimental Diabetes Research
Volume 2012 (2012), Article ID 538474, 6 pages
Impact of Maternal Diabetes on Epigenetic Modifications Leading to Diseases in the Offspring
12nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, 11528 Athens, Greece
21st Department of Obstetrics and Gynecology, Alexandra Hospital, School of Medicine, University of Athens, 11528 Athens, Greece
3Neonatal Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, 11528 Athens, Greece
4Department of Obstetrics and Gynecology, School of Medicine, University of Thessaly, 41334 Larissa, Greece
53rd Department of Obstetrics and Gynecology, Attiko Hospital, University of Athens, 12462 Athens, Greece
Received 18 September 2012; Accepted 26 October 2012
Academic Editor: Aristidis Veves
Copyright © 2012 Nikolaos Vrachnis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- N. Vrachnis, P. Belitsos, S. Sifakis et al., “Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus,” International Journal of Endocrinology, vol. 2012, Article ID 549748, 12 pages, 2012.
- N. Vitoratos, N. Vrachnis, G. Valsamakis, K. Panoulis, and G. Creatsas, “Perinatal mortality in diabetic pregnancy,” Annals of the New York Academy of Sciences, vol. 1205, pp. 94–98, 2010.
- N. Vrachnis, A. Augoulea, Z. Iliodromiti, I. Lambrinoudaki, S. Sifakis, and G. Creatsas, “Previous gestational diabetes mellitus and markers of cardiovascular risk,” International Journal of Endocrinology, vol. 2012, Article ID 458610, 6 pages, 2012.
- D. Simmons, “Epidemiology of diabetes in pregnancy,” in Practical Management of Diabetes in Pregnancy, D. McCance and M. Maresh, Eds., Blackwell Publishing., London, UK, 2010.
- IADPSG Consensus Panel, “International association of diabetes and pregnancy study groups (IADPSG) recommendations on the diagnosis and classification of hyperglycemia in pregnancy,” Diabetes Care, vol. 33, no. 7, pp. 676–682, 2010.
- F. Galtier, “Definition, epidemiology, risk factors,” Diabetes & Metabolism, vol. 36, no. 6, pp. 628–651, 2010.
- A. E. Evensen, “Update on gestational diabetes mellitus,” Primary Care, vol. 39, no. 1, pp. 83–94, 2012.
- M. Lampl and P. Jeanty, “Exposure to maternal diabetes is associated with altered fetal growth patterns: a hypothesis regarding metabolic allocation to growth under hyperglycemic-hypoxemic conditions,” American Journal of Human Biology, vol. 16, no. 3, pp. 237–263, 2004.
- T. Jansson, I. Cetin, T. L. Powell et al., “Placental transport and metabolism in fetal overgrowth—a workshop report,” Placenta, vol. 27, pp. 109–113, 2006.
- M. A. Ashworth, F. N. Leach, and R. D. Milner, “Development of insulin secretion in the human fetus,” Archives of Disease in Childhood, vol. 48, no. 2, pp. 151–152, 1973.
- P. M. Catalano, A. Thomas, L. Huston-Presley, and S. B. Amini, “Increased fetal adiposity: a very sensitive marker of abnormal in utero development,” American Journal of Obstetrics and Gynecology, vol. 189, no. 6, pp. 1698–1704, 2003.
- A. Ericsson, K. Säljö, E. Sjöstrand et al., “Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport,” Journal of Physiology, vol. 581, no. 3, pp. 1323–1332, 2007.
- D. J. Pettitt, W. C. Knowler, and P. H. Bennett, “Obesity in offspring of diabetic Pima Indian women despite normal birth weight,” Diabetes Care, vol. 10, no. 1, pp. 76–80, 1987.
- B. L. Silverman, T. Rizzo, O. C. Green et al., “Long-term prospective evaluation of offspring of diabetic mothers,” Diabetes, vol. 40, supplement 2, pp. 121–125, 1991.
- B. L. Silverman, B. E. Metzger, N. H. Cho, and C. A. Loeb, “Impaired glucose tolerance in adolescent offspring of diabetic mothers: relationship to fetal hyperinsulinism,” Diabetes Care, vol. 18, no. 5, pp. 611–617, 1995.
- A. Plagemann, T. Harder, R. Kohlhoff, W. Rohde, and G. Dörner, “Glucose tolerance and insulin secretion in children of mothers with pregestational IDDM or gestational diabetes,” Diabetologia, vol. 40, no. 9, pp. 1094–1100, 1997.
- D. Dabelea and D. J. Pettitt, “Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility,” Journal of Pediatric Endocrinology and Metabolism, vol. 14, no. 8, pp. 1085–1091, 2001.
- N. Halfon, P. A. Verhoef, and A. A. Kuo, “Childhood antecedents to adult cardiovascular disease,” Pediatrics in Review, vol. 33, no. 2, pp. 51–60, 2012.
- J. Rasanen and P. Kirkinen, “Growth and function of human fetal heart in normal, hypertensive and diabetic pregnancy,” Acta Obstetricia et Gynecologica Scandinavica, vol. 66, no. 4, pp. 349–353, 1987.
- J. C. Bunt, P. Antonio Tataranni, and A. D. Salbe, “Intrauterine exposure to diabetes is a determinant of hemoglobin A1c and systolic blood pressure in pima indian children,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3225–3229, 2005.
- J. Manderson, B. Mullan, C. Patterson, D. Hadden, A. Traub, and D. McCance, “Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy,” Diabetologia, vol. 45, no. 7, pp. 991–996, 2002.
- N. M. Mordwinkin, J. G. Ouzounian, L. Yedigarova, M. N. Montoro, S. G. Louie, and K. E. Rodgers, “Alteration of endothelial function markers in women with gestational diabetes and their fetuses,” Journal of Maternal-Fetal and Neonatal Medicine. In press.
- L. Aerts and F. A. Van Assche, “Animal evidence for the transgenerational development of diabetes mellitus,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 5-6, pp. 894–903, 2006.
- R. J. Gill-Randall, D. Adams, R. L. Ollerton, and J. C. Alcolado, “Is human Type 2 diabetes maternally inherited? Insights from an animal model,” Diabetic Medicine, vol. 21, no. 7, pp. 759–762, 2004.
- D. J. Petitt, H. B. Baird, and K. A. Aleck, “Excessive obesity in offspring of Pima Indian women with diabetes during pregnancy,” The New England Journal of Medicine, vol. 308, no. 5, pp. 242–245, 1983.
- D. Dabelea, W. C. Knowler, and D. J. Pettitt, “Effect of diabetes in pregnancy on offspring: follow-up research in the Pima Indians,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 9, no. 1, pp. 83–88, 2000.
- T. Harder, K. Franke, R. Kohlhoff, and A. Plagemann, “Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type I,” Gynecologic and Obstetric Investigation, vol. 51, no. 3, pp. 160–164, 2001.
- M. McLean, D. Chipps, and N. W. Cheung, “Mother to child transmission of diabetes mellitus: does gestational diabetes program Type 2 diabetes in the next generation?” Diabetic Medicine, vol. 23, no. 11, pp. 1213–1215, 2006.
- D. Dabelea, R. L. Hanson, R. S. Lindsay et al., “Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a Study of Discordant Sibships,” Diabetes, vol. 49, no. 12, pp. 2208–2211, 2000.
- A. Stride, M. Shepherd, T. M. Frayling, M. P. Bulman, S. Ellard, and A. T. Hattersley, “Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1α gene mutation carriers,” Diabetes Care, vol. 25, no. 12, pp. 2287–2291, 2002.
- D. J. Pettitt and W. C. Knowler, “Long-term effects of the intrauterine environment, birth weight, and breast-feeding in Pima Indians,” Diabetes Care, vol. 21, supplement 2, pp. B138–B141, 1998.
- L. Marroquí, A. Gonzalez, P. Ñeco et al., “Role of leptin in the pancreatic β-cell: effects and signaling pathways,” Journal of Molecular Endocrinology, vol. 49, no. 1, pp. 9–17, 2012.
- J. B. Susa, J. M. Boylan, P. Sehgal, and R. Schwartz, “Persistence of impaired insulin secretion in infant rhesus monkeys that had been hyperinsulinemic in utero,” Journal of Clinical Endocrinology and Metabolism, vol. 75, no. 1, pp. 265–269, 1992.
- B. Persson, M. Westgren, G. Celsi, E. Nord, and E. Örtqvist, “Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers,” Hormone and Metabolic Research, vol. 31, no. 8, pp. 467–471, 1999.
- H. Christou, J. M. Connors, M. Ziotopoulou et al., “Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 2, pp. 935–938, 2001.
- J. M. Atègbo, O. Grissa, A. Yessoufou et al., “Modulation of adipokines and cytokines in gestational diabetes and macrosomia,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 10, pp. 4137–4143, 2006.
- A. Yessoufou and K. Moutairou, “Maternal diabetes in pregnancy: early and long-term outcomes on the offspring and the concept of ‘metabolic memory’,” Experimental Diabetes Research, vol. 2011, Article ID 218598, 12 pages, 2011.
- A. L. Fowden and D. J. Hill, “Intra-uterine programming of the endocrine pancreas,” British Medical Bulletin, vol. 60, pp. 123–142, 2001.
- E. Pinter, J. Haigh, A. Nagy, and J. A. Madri, “Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation,” American Journal of Pathology, vol. 158, no. 4, pp. 1199–1206, 2001.