Blockade of Renin Angiotensin System Increased Resistance to STZ-Induced Diabetes in Rats with Long-Term High-Fat Diet

Table 2

Results of hyperinsulinemic euglycemic clamp, IVGTT, and IVIRT (𝑥±𝑠).

Group	𝑛	GIR; (mg·kg^−1·min^−1)	AUCG0–60; (mmol·L^−1·min^−1)	AUCI0–10; (mIU·L^−1·min^−1)	AUCI10–60; (mIU·L^−1·min^−1)	AUCI0–60; (mIU·L^−1·min^−1)
NC	5	7.80±0.51	57.12±5.38	277.29±5.46	94.57±2.35	371.85±5.97
HF	5	5.32±0.90^∗	73.63±6.69^∗	264.46±3.51^∗	159.67±7.98^∗	424.13±9.20^∗
HF+S	5	ND	180.79±7.31^∗#	122.84±11.84^∗#	94.65±24.67^#	217.49±35.67^∗#
HF+T+S	5	ND	122.68 ±18.44∗#∇	198.13±13.12^∗#∇	124.88±7.80^∗#★	326.01±19.68^∗#∇

NC: normal control group; HF: high-fat diet group; HF+S: high-fat diet plus STZ intraperitoneal injection group; HF+T+S: high-fat diet plus telmisartan intervention and STZ intraperitoneal injection group.
GIR: glucose infusion rate; AUCG: area under the curve of glucose; AUCI: area under the curve of insulin.
^●P < 0.05; ^∗𝑃<0.01 as compared with NC group; ^▲P < 0.05, ^#<0.01 as compared with HF group; ^★<0.05, ^∇<0.01 as compared with HF+S group.