Research Article

Oxidative/Nitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits: Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide

Table 1

Effects of pioglitazone and repaglinide on oxidative/nitrosative stress parameters in the aqueous humor of control and hyperglycemic rabbits.

Group CGroup CPGroup CRGroup HGroup HPGroup HR

TAS (mmol/mL) 0.67 ± 0.09a2.37 ± 0.14a,b1.56 ± 0.15b
AA (μg/mL) 3.02 ± 0.38a21.87 ± 1.18a,b12.62 ± 1.36b
GSH (nmol/mL) 117.7 ± 3.32a76.14 ± 6.56a131.4 ± 5.86b91.06 ± 8.17a,b
NO2 (nmol/mL) 113.4 ± 7.63a102.0 ± 8.78a142.5 ± 2.54a
LPO (nmol/mL) 2.64 ± 0.14a1.21 ± 0.11a,b1.45 ± 0.17a,b
PCG (nmol/mg protein) 24.13 ± 1.63a44.49 ± 2.15a20.46 ± 2.96b40.46 ± 3.57a
AOPP (nmol/mg protein) 16.15 ± 2.24a4.31 ± 0.18a,b19.29 ± 0.88a,b

Values are mean ± SEM ( ). TAS: total antioxidant status, AA: ascorbic acid, GSH: glutathione, NO2: total nitrites, PCG: protein carbonyls, AOPP: advanced oxidized protein products. C: control rabbits, CP: control rabbits treated with pioglitazone, CR: control rabbits treated with repaglinide, H: hyperglycemic rabbits, HP: hyperglycemic rabbits treated with pioglitazone, HR: hyperglycemic rabbits treated with repaglinide. aSignificant at versus Group C. bSignificant at versus Group H.