Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

Figure 3

Intracellular high-glucose metabolism and oxidative stress. When intracellular glucose concentration increases in target cells of diabetes complications, it causes increased mitochondrial production of ROS and activates negative feedback loops to protect target cells from ROS-induced damage. The maladaptive response, however, leads to the activation of metabolic pathways that are involved in the diabetes vascular disfunction.