Role of Transcription Factor Modifications in the Pathogenesis of Insulin Resistance

Table 1

The target genes of the transcription factors.

Transcription factor	Target gene		Reference
	Gene symbol	Description
FOXO1	G6PC	Glucose-6-phosphatase	[36]
	Pck1	Phosphoenolpyruvates carboxykinase1	[181]
	Ppargc1a	Peroxisome proliferator-activated receptor-coactivator-1 alpha	[38]
	Pdx1	Pancreatic and duodenal homeobox 1	[101]
	NeuroD	Neurogenic differentiation	[107]
	MafA	V-maf (maf musculoaponeurotic fibrosarcoma) oncogene homolog A	[107]
	ADIPOQ	Adiponectin	[170]
CREB	G6pc	Glucose-6-phosphatease	[57]
	Pck1	Phosphoenolpyruvates carboxykinase	[57]
	Ppargc1a	Peroxisome proliferator-activated receptor-coactivator-1 alpha	[57]
SREBP-1c	ACLY	ATP-citrate lyase	[182, 183]
	Acaca	Acetyl-CoA carboxylase alpha	[184]
	ACACB	Acetyl-CoA carboxylase beta	[185]
	Fasn	Fatty acid synthase	[186]
	Scd1	Stearoyl-coenzyme A desaturase 1	[187]
	Elovl6	ELOVL fatty acid elongase 6	[188]
ChREBP	Pklr	Pyruvate kinase, liver, and RBC	[189]
	Acc1	Acetyl-CoA carboxylase 1	[190]
	Fasn	Fatty acid synthase	[191]
NF-κB	TNF-α	Tumor necrosis factor alpha	[192]
	IL-6	Interleukin 6	[193]
	MCP-1	Monocyte chemotactic protein 1	[194]
Sp1	LEP	Leptin	[195]
	LETN	Resistin	[196]