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Experimental Diabetes Research
Volume 2012 (2012), Article ID 732027, 8 pages
http://dx.doi.org/10.1155/2012/732027
Research Article

Impact of Diabetes and Hyperglycemia on Survival in Advanced Breast Cancer Patients

1Clínica de Cáncer de Mama, Instituto Nacional de Cancerología (INCan), 14080 México, DF, Mexico
2Departamento de Oncología Médica, INCan, 14080 México, DF, Mexico
3Unidad de Investigación Biomédica en Cáncer, INCan and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México, DF, Mexico

Received 1 February 2012; Revised 31 May 2012; Accepted 18 June 2012

Academic Editor: Chien-Jen Chen

Copyright © 2012 Cynthia Villarreal-Garza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. We examined the impact of diabetes and hyperglycemia on cancer-specific survival of patients with metastatic or recurrent breast cancer (BC). Methods. We performed a retrospective analysis of 265 patients with advanced BC receiving palliative chemotherapy. BC-specific mortality was compared for diabetic and nondiabetic patients as well as for patients that presented hyperglycemia during treatment. Results. No difference was observed between the diabetic and nondiabetic patients in terms of overall survival (OS). A difference in OS was observed between nondiabetic patients and diabetic patients who had hyperglycemia. The OS was greater in diabetic patients with proper metabolic control than diabetic patients with hyperglycemia. The risk of death was higher in patients with mean glucose levels > 130 mg/dL during treatment. Several factors were associated with poor OS: tumor stage, hormone-receptor-negative tumors, HER2 negative disease, multiple metastatic sites, presence of visceral metastases, and mean glucose > 130 mg/dL. Conclusion. Elevated glucose levels are associated with a poor outcome in diabetic and nondiabetic patients in contrast to patients with normoglycemic levels, conferring an elevated risk of death. According to these results, clinicians should monitor glucose levels during treatment for advanced breast cancer disease and take action to maintain normal glucose levels.