Research Article
Impact of Diabetes and Hyperglycemia on Survival in Advanced Breast Cancer Patients
Table 2
Univariate and multivariate analyses according to overall survival.
| Variable | Overall survival (median, months) | | HR (95% CI) | P |
| Age (years) | | | 1.2 | 0.303 | Age < 49 | 26 | 0.301 | (0.8–1.9) | Age 49 | 26 |
| Tumor stage | | | | <0.001 | 1-2 | 38 | <0.001 | 2.7 (1.7–4.4) | 3-4 | 17 |
| Nodes | | | | 0.091 | Negative | 38 | 0.276 | 0.6 (0.4–1.1) | Positive | 24 |
| Grade | | | | 0.083 | 1-2 | 39 | 0.004 | 1.5 (0.9–2.2) | 3 | 20 |
| Hormone receptor | | | | 0.003 | Positive | 37 | <0.001 | 0.2 (0.1–0.6) | Negative | 18 |
| HER2 | | | | 0.015 | Positive | 26 | 0.824 | 0.3 (0.1–0.8) | Negative | 24 |
| Triple-negative | | | | 0.072 | Positive | 15 | 0.005 | 0.4 (0.1–1.1) | Negative | 31 |
| Metastatic site | | | | 0.047 | Single | 38 | 0.018 | 1.6 (1.0–2.4) | Multiple | 24 |
| Type of metastases | | | | 0.042 | Nonvisceral | 38 | 0.019 | 1.6 (1.0–2.5) | Visceral | 23 |
| Overweight or obesity at recurrence | | | | 0.680 | Yes | 31 | 0.310 | 0.9 (0.6–1.4) | No | 23 |
| Diabetes at recurrence | | | | 0.709 | No | 26 | 0.227 | 0.9 (0.4–1.9) | Yes | 18 |
| Mean glucose >130 | | | | 0.034 | No | 27 | 0.023 | 2.8 (1.1–7.3) | Yes | 12 |
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HR: Hazard ratio.
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