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Experimental Diabetes Research
Volume 2012 (2012), Article ID 758614, 11 pages
Research Article

Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats

1School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
2Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, QLD 4350, Australia
3Department of Entomology and University of California Davis Cancer Center, University of California, Davis, CA 95616, USA

Received 30 May 2011; Revised 15 July 2011; Accepted 15 July 2011

Academic Editor: Yingmei Zhang

Copyright © 2012 Abishek Iyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Yan Liu, Huaixin Dang, Dan Li, Wei Pang, Bruce D. Hammock, and Yi Zhu, “Inhibition of Soluble Epoxide Hydrolase Attenuates High-Fat-Diet-Induced Hepatic Steatosis by Reduced Systemic Inflammatory Status in Mice,” Plos One, vol. 7, no. 6, 2012. View at Publisher · View at Google Scholar
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  • Ahmed A. Elmarakby, Jessica Faulkner, Chelsey Pye, Katelyn Rouch, Abdulmohsin Alhashim, Krishna Rao Maddipati, and Babak Baban, “Role of haem oxygenase in the renoprotective effects of soluble epoxide hydrolase inhibition in diabetic spontaneously hypertensive rats,” Clinical Science, vol. 125, no. 7, pp. 349–359, 2013. View at Publisher · View at Google Scholar
  • Lisa A. Morgan, Alan R. Olzinski, John J. Upson, Shufang Zhao, Tao Wang, Stephen H. Eisennagel, Bao Hoang, James R. Tunstead, Joseph P. Marino, Robert N. Willette, Beat M. Jucker, and David J. Behm, “Soluble Epoxide Hydrolase Inhibition Does Not Prevent Cardiac Remodeling and Dysfunction After Aortic Constriction in Rats and Mice,” Journal of Cardiovascular Pharmacology, vol. 61, no. 4, pp. 291–301, 2013. View at Publisher · View at Google Scholar
  • Christophe Morisseau, and Bruce D. Hammock, “Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health,” Annual Review of Pharmacology and Toxicology, vol. 53, no. 1, pp. 37–58, 2013. View at Publisher · View at Google Scholar
  • Claudia E. Ramirez, Megan M. Shuey, Ginger L. Milne, Kimberly Gilbert, Nian Hui, Chang Yu, James M. Luther, and Nancy J. Brown, “Arg287Gln VARIANT OF EPHX2 AND EPOXYEICOSATRIENOIC ACIDS ARE ASSOCIATED WITH INSULIN SENSITIVITY IN HUMANS,” Prostaglandins & Other Lipid Mediators, 2014. View at Publisher · View at Google Scholar
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  • Frederick W. Goldberg, Alexander G. Dossetter, James S. Scott, Graeme R. Robb, Scott Boyd, Sam D. Groombridge, Paul D. Kemmitt, Tove Sjoegren, Pablo Morentin Gutierrez, Joanne deSchoolmeester, John G. Swales, Andrew V. Turnbull, and Martin J. Wild, “Optimization of Brain Penetrant 11 beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice,” Journal of Medicinal Chemistry, vol. 57, no. 3, pp. 970–986, 2014. View at Publisher · View at Google Scholar
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  • Todd R. Harris, Ahmed Bettaieb, Sean Kodani, Hua Dong, Richard Myers, Nipavan Chiamvimonvat, Fawaz G. Haj, and Bruce D. Hammock, “Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice,” Toxicology and Applied Pharmacology, 2015. View at Publisher · View at Google Scholar