Table 1: Physiological parameters of CS-, HCHF-, CS + t-AUCB-, HCHF + t-AUCB-treated rats. * versus CS-fed rats; ** versus HCHF-fed rats.

ParameterCS (16 weeks)HCHF (16 weeks)CS + t-AUCB
(16 weeks)
HCHF + t-AUCB
(16 weeks)

Body weight @ week 16 (g)422 ± 6
( )
515.8 ± 11.9
( )
415 ± 6
( )
515.7 ± 13
( )
Abdominal fat deposition (mg/mm tibial length)401 ± 56
( )
746 ± 67*
( )
270 ± 38
( )
674 ± 99*
( )
Total fat mass (g)56 ± 5
( )
139.4 ± 16*
( )
46.7 ± 8
( )
154.3 ± 19*
( )
Heart rate (bpm)249 ± 9
( )
251 ± 21
( )
262 ± 13
( )
265 ± 8
( )
LVIDd (mm)6.73 ± 0.2
( )
7.54 ± 0.18*
( )
6.8 ± 0.2**
( )
6.8 ± 0.2**
( )
LVPWd (mm)1.69 ± 0.1
( )
1.95 ± 0.1
( )
1.69 ± 0.08
( )
1.9 ± 0.1
( )
LVIDs (mm)3.9 ± 0.3
( )
4.9 ± 0.2*
( )
3.6 ± 0.2**
( )
4.2 ± 0.2**
( )
E/A ratio1.6 ± 0.1
( )
1.2 ± 0.1*
( )
2.0 ± 0.2**
( )
1.5 ± 0.04**
( )
Ejection fraction (%)79 ± 4
( )
72 ± 2
( )
85 ± 2**
( )
76 ± 3
( )
Cardiac output (mL/min)63.4 ± 6.4
( )
83.8 ± 9
( )
81.8 ± 10
( )
72.2 ± 7
( )
Estimated LV mass (g)0.74 ± 0.05
( )
1.0 ± 0.05*
( )
0.77 ± 0.05**
( )
0.84 ± 0.04**
( )
Diastolic stiffness constant (κ)20.5 ± 1.9
( )
28.9 ± 1*
( )
22.8 ± 0.4**
( )
20.1 ± 0.1**
( )
Plasma insulin concentrations2.2 ± 0.4
( )
4.2 ± 0.3*
( )
4.7 ± 1.1*
( )
5.2 ± 1*
( )
Plasma leptin concentrations6.8 ± 0.86
( )
8.6 ± 1.1
( )
6.9 ± 0.8
( )
9.7 ± 0.5
( )
Plasma ALT activity, U/L37 ± 0.6
( )
59.6 ± 0.3*
( )
52.3 ± 2*
( )
49.4 ± 3.2*
( )
Plasma AST activity, U/L73.2 ± 5.6
( )
105.3 ± 9*
( )
68.2 ± 3.2**
( )
69.7 ± 5.7**
( )
Plasma ALP activity, U/L174 ± 19
( )
251 ± 21*
( )
192 ± 11**
( )
274 ± 29*
( )
Plasma LDH activity, U/L204 ± 23
( )
497 ± 14*
( )
180 ± 56**
( )
184 ± 26**
( )
LV + septum (mg/mm tibial length)18.9 ± 0.9
( )
21.8 ± 1.1
( )
20.3 ± 1.5
( )
20.5 ± 0.8
( )
Right ventricle (mg/mm tibial length)4.14 ± 0.3
( )
4.48 ± 0.3
( )
3.7 ± 0.2
( )
4.4 ± 0.3
( )
Liver (mg/mm tibial length)234 ± 14
( )
287 ± 12*
( )
264 ± 15
( )
292 ± 19*
( )
Islets as % area of pancreas6.2 ± 1.4
( )
15.3 ± 1.5
( )
5.2 ± 0.1
( )
16.7 ± 1.3
( )
Number of α cells/islet16.9 ± 0.5
39.3 ± 1.2
22.4 ± 1.9
38.6 ± 1.4
( )
Number of β cells/islet72.3 ± 2.8
( )
124.7 ± 7.2
( )
117.1 ± 4.1
( )
149.8 ± 6.3
( )