Pentoxifylline Attenuates Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis by Suppressing TNF-α Expression and Endoplasmic Reticulum Stress
Figure 4
Hepatic TNF-α gene expression after 4 weeks of treatment with an MCD diet and pentoxifylline. There was a significant increase in liver TNF-α mRNA levels in rats fed MCD (groups III and IV). Administration of PTX in MCD diet rats significantly decreased the TNF-α mRNA expression. Results are shown as mean ± SEM. ***P < 0.001 versus untreated control group. : MCD plus saline versus MCD plus PTX group.
