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Experimental Diabetes Research
Volume 2012 (2012), Article ID 789174, 12 pages
Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms
1Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy
2Clinical Pathology, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy
3Endocrinology, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy
Received 29 January 2012; Accepted 10 April 2012
Academic Editor: Chien-Jen Chen
Copyright © 2012 Biagio Arcidiacono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [67 citations]
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- Dan Wang, Mitchell L. Wise, Feng Li, and Moul Dey, “Phytochemicals Attenuating Aberrant Activation of beta-Catenin in Cancer Cells,” Plos One, vol. 7, no. 12, 2012.
- Dino Rotondo, and Jillian Davidson, “Genetics and molecular biology,” Current Opinion in Lipidology, vol. 23, no. 5, pp. 501–502, 2012.
- Chengeng Liu, Yue Wei, Jianmin Wang, Langan Pi, Jianjun Huang, and Peichang Wang, “Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure,” Clinical and Developmental Immunology, vol. 2012, pp. 1–6, 2012.
- Sandra Maria Barbalho, Maricelma da Silva Soares de Souza, Júlio César de Paula e Silva, Claudemir Gregório Mendes, Gabriela Aparecida de Oliveira, and Flávia M. V Farinazzi-Machado, “Yellow passion fruit rind (Passiflora edulis): an industrial waste or an adjuvant in the maintenance of glycemia and prevention of dyslipidemia?,” Journal of Diabetes Research and Clinical Metabolism, vol. 1, no. 1, pp. 5, 2012.
- Arlette Gratas-Delamarche, Frédéric Derbré, Sophie Vincent, and Josiane Cillard, “Physical inactivity, insulin resistance and the oxidative-inflammatory loop,” Free Radical Research, pp. 1–37, 2013.
- Amaresh C. Panda, Ioannis Grammatikakis, and Je-Hyun Yoon, “Posttranscriptional Regulation of Insulin Family Ligands and Receptors,” International Journal of Molecular Sciences, vol. 14, no. 9, pp. 19202–19229, 2013.
- Rebecca L. Glaser, and Constantine Dimitrakakis, “Reduced breast cancer incidence in women treated with subcutaneous testosterone, or testosterone with anastrozole: A prospective, observational study,” Maturitas, 2013.
- Brenee King, Yu Jiang, Xiaoyu Su, Jianteng Xu, Linglin Xie, Joseph Standard, and Weiqun Wang, “Weight control, endocrine hormones and cancer prevention,” Experimental Biology and Medicine, vol. 238, no. 5, pp. 502–508, 2013.
- Chin-Hsiao Tseng, “Pioglitazone does not affect the risk of ovarian cancer: Analysis of a nationwide reimbursement database in Taiwan,” Gynecologic Oncology, 2013.
- Cheryl L. Rock, Chetna Pande, Shirley W. Flatt, Carl Ying, Bilge Pakiz, Barbara A. Parker, Kathryn Williams, Wayne A. Bardwell, Dennis D. Heath, and Jeanne F. Nichols, “Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese,” Clinical Breast Cancer, vol. 13, no. 3, pp. 188–195, 2013.
- Hua-Fen Chen, Ming-Der Liu, Peter Chen, Li-Huan Chen, Ya-Hui Chang, Pei-Chun Wen, and Chung-Yi Li, “Risks of Breast and Endometrial Cancer in Women with Diabetes: A Population-Based Cohort Study,” PLoS ONE, vol. 8, no. 6, 2013.
- Joyce V. Lee, Supriya A. Shah, and Kathryn E. Wellen, “Obesity, cancer and acetyl-CoA metabolism,” Drug Discovery Today: Disease Mechanisms, 2013.
- A. J. Krentz, A. Viljoen, and A. Sinclair, “Insulin resistance: a risk marker for disease and disability in the older person,” Diabetic Medicine, vol. 30, no. 5, pp. 535–548, 2013.
- Chin-Hsiao Tseng, “Diabetes and thyroid cancer mortality: a 12-year prospective follow-up of Taiwanese,” European Journal of Clinical Investigation, vol. 43, no. 6, pp. 595–601, 2013.
- A. B. Crujeiras, A. Díaz-Lagares, M. C. Carreira, M. Amil, and F. F. Casanueva, “Oxidative stress associated to dysfunctional adipose tissue: a potential link between obesity, type 2 diabetes mellitus and breast cancer,” Free Radical Research, vol. 47, no. 4, pp. 243–256, 2013.
- Chin-Hsiao Tseng, “Diabetes, insulin use, smoking, and pancreatic cancer mortality in Taiwan,” Acta Diabetologica, 2013.
- K B Greer, A Kresak, B Bednarchik, D Dawson, L Li, A Chak, and J Willis, “Insulin/Insulin-Like Growth Factor-1 Pathway in Barrett’s Carcinogenesis,” Clinical and Translational Gastroenterology, vol. 4, no. 3, pp. e31, 2013.
- Kevin P. Keenan, Matthew A. Wallig, and Wanda M. Haschek, “Nature via nurture: Effect of diet on health, obesity, and safety assessment,” Toxicologic Pathology, vol. 41, no. 2, pp. 190–209, 2013.
- Jeffrey J. W. Verschuren, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom, J. Wouter Jukema, Stella Trompet, Joris Deelen, David J. Stott, Naveed Sattar, Brendan M. Buckley, Ian Ford, Bastiaan T. Heijmans, and Henk-Jan Guchelaar, “Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data,” PLoS ONE, vol. 8, no. 2, 2013.
- Ana B. Crujeiras, M. Angeles Zulet, Patricia Lopez-Legarrea, Rocío de la Inglesia, María Pardo, Marcos C. Carreira, J. Alfredo Martínez, and Felipe F. Casanueva, “Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients,” Metabolism, 2013.
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- Veronika M. Gebhart, and Gustav F. Jirikowski, “Estrogen dependent expression of Sex Hormone Binding Globulin in PC 12 cells,” Steroids, 2013.
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- Edward C. Suarez, and Nicole L. Schramm-Sapyta, “Race differences in the relation of vitamins A, C, E and β-carotene to metabolic and inflammatory biomarkers,” Nutrition Research, 2013.
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- Hala Ahmadieh, and Sami T. Azar, “Type 2 Diabetes Mellitus, Oral Diabetic Medications, Insulin Therapy, and Overall Breast Cancer Risk,” ISRN Endocrinology, vol. 2013, pp. 1–8, 2013.
- Samy L. Habib, and Maciej Rojna, “Diabetes and Risk of Cancer,” ISRN Oncology, vol. 2013, pp. 1–16, 2013.
- Rosalyne L. Westley, and Felicity E. B. May, “A Twenty-First Century Cancer Epidemic Caused by Obesity: The Involvement of Insulin, Diabetes, and Insulin-Like Growth Factors,” International Journal of Endocrinology, vol. 2013, pp. 1–37, 2013.
- Lena Secky, Martin Svoboda, Lukas Klameth, Erika Bajna, Gerhard Hamilton, Robert Zeillinger, Walter Jäger, and Theresia Thalhammer, “The Sulfatase Pathway for Estrogen Formation: Targets for the Treatment and Diagnosis of Hormone-Associated Tumors,” Journal of Drug Delivery, vol. 2013, pp. 1–13, 2013.
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- E.M. Strage, M.S. Lewitt, J.M. Hanson, U. Olsson, F. Norrvik, I. Lilliehöök, B.S. Holst, and T. Fall, “Relationship among Insulin Resistance, Growth Hormone, and Insulin-Like Growth Factor I Concentrations in Diestrous Swedish Elkhounds,” Journal of Veterinary Internal Medicine, 2014.
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- S. O'Neill, and L. O'Driscoll, “Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies,” Obesity Reviews, 2014.
- A. B. Crujeiras, and F. F. Casanueva, “Obesity and the reproductive system disorders: epigenetics as a potential bridge,” Human Reproduction Update, 2014.
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- Anna H. Wu, Allison W. Kurian, Marilyn L. Kwan, Esther M. John, Yani Lu, Theresa H. M. Keegan, Scarlett Lin Gomez, Iona Cheng, Salma Shariff-Marco, Bette J. Caan, Valerie S. Lee, Jane Sullivan-Halley, Chiu-Chen Tseng, Leslie Bernstein, Richard Sposto, and Cheryl Vigen, “Diabetes and Other Comorbidities in Breast Cancer Survival by Race/Ethnicity: The California Breast Cancer Survivorship Consortium (CBCSC),” Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 2, pp. 361–368, 2015.
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- Jason You, Hushan Yang, Yinzhi Lai, Lindsay Simon, Jen Au, and Ashlie L. Burkart, “ARID2, p110α, p53 and β-catenin Protein Expression in Hepatocellular Carcinoma and Clinicopathologic Implications,” Human Pathology, 2015.
- Willemijn A. van Gemert, Evelyn M. Monninkhof, Anne M. May, Petra H. Peeters, and Albertine J. Schuit, “Effect of Exercise on Insulin Sensitivity in Healthy Postmenopausal Women: The SHAPE Study,” Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 1, pp. 81–87, 2015.