Journal of Diabetes Research

Research Article

Oxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines

Table 1

Panel of 90 target genes for analysis by TLDA expression profiling. Candidate genes have been shown by pathway-based microanalysis to be deregulated in T2D skeletal muscle, are reported in the literature to be involved in oxidative metabolism or the oxidative stress response, or are reported in the literature to be key players in diabetes pathways/deregulated in T2D.


Panel of 90 target genes for analysis by TLDA expression profiling

Deregulated in T2D skeletal muscle	*Alas1*	*Atp5c1*	*Atp5g1*	*Atp5g2*	*Atp5g3*	*Ckmt1*	*Cox4i1*
	*Cox6a1*	*Cox6c*	*Nrf1*	*Pdx1*	*Pkm2*	*Por*	*Sdhc*
	*Slc25a4*	*Ucp2*	*Uros*	*Eif2ak3*	*Sdhb*	*Uqcrc1*	*Cox5b*
	Atp5o	Cox7b	Cyc1	Atp5j	Ndufa5	Ndufa8	Ndufb5
	Ndufb6	Ndufs2	Ndufs3	Ppara	Ppard	Pparg	Ppargc1a
	Sdha

Involved in oxidative metabolism and the oxidative stress response	Aco1	Ccng1	Cdkn1a	Cxcl10	Ddit3	Dnaja1	Fmo1
	Gck	Gsr	Hspa4	Hspa5	Igfbp2	Il18	Ins1
	Ireb2	Nfkb1	Nfkbia	Pck1	Rad23a	Sod1	Tnf
	Tp53	Txn2	Txnip	Ung	Xbp1	Ercc1	Mtor
	Nampt	Ndufaf1	Nfe2l2	Prkcd	Prkcz	Shc1

Key players in T2D pathways

Cell cycle and apoptosis	Crls1	Hdac4	Hdac5	Hgf	Igf1	Suv39h1
Cellular and energy metabolism and homeostasis, including glucose homeostasis	Foxo1	Gckr	Hagh	Hk1	Prkaa2	Sirt1
Immune and inflammatory processes	Crp	Il1b	Il1rn	Il6	Rage
Insulin signaling and homeostasis	Gcg	Insr	Kcnj11