Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes
Figure 3
Knockdown of SHP-1 by siRNA blunts HG-induced cell apoptosis in MHMEC. (a) Caspase-3 ELISA analysis showing that transfection of MHMEC with SHP-1 siRNA significantly attenuated caspase-3 activation under NG or HG conditions ( cell lines, *). (b) TUNEL staining showing that MHMEC transfected with SHP-1 siRNA significantly inhibited high glucose-induced endothelial cell apoptosis ( cell lines, *).
