Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes
Figure 6
Treatment with PTP inhibitor restores the angiogenic response to Ang-1 in diabetic db/db mouse. (a) Representative images of Ang-1-induced aortic explants sprouting in C57BL/6J and diabetic db/db mice. Stimulation of C57BL/6J mouse aortic explants with Ang-1 (250 ng/mL) leads to robust vessel outgrowth. Ang-1-induced vessel outgrowth was blunted in the db/db mouse aortic explants. (b) Representative images of Ang-1-induced vessel outgrowth in the db/db mouse aortic explants in the presence and absence of PTP inhibitor OV. (c) Quantitative areas of vessel outgrowth in db/db mouse aortic explants showing Ang-1-induced vessel outgrowth were significantly increased in the presence of PTP inhibitor OV (–8 mice, *).
