Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes
Figure 7
Systemic treatment with the PTP inhibitor attenuates SHP-1 expression and increases eNOS and myocardial capillary density in db/db mice. (a) Western blot analysis showing that treatment with BMOV for 2 weeks leads to a significant suppression of SHP-1 expression in the db/db mice compared to db/db control without BMOV ( mice, *). (b) Western blot analysis showing that treatment with BMOV for 2 weeks results in a significant increase in eNOS expression in the db/db mice compared to db/db control (-4 mice, *). (c) Myocardial capillary density was significantly increased in the BMOV-treated db/db mice compared to db/db control with BMOV (, *). (d) Quantitation of areas of vessel outgrowth showing Ang-1-induced vessel explants sprouting is significantly improved in the BMOV-treated db/db mice compared to db/db control group (–8 mice, *).
