Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet

Table 1

Fasting serum level of glucose, insulin, and HOMA-IR.

	DIO/HF	DIO/CF	DIO-R/HF	DIO-R/CF	CF
FPG (mmol/L)
0 W	2.61±0.14	2.93±0.10	2.94±0.29	2.86±0.14	2.94±0.04
10 W	5.16±0.12^ab	5.27±0.11^ab	4.24±0.09	4.10±0.13	4.12±0.07
18 W	4.96±0.10	4.73±0.20	4.62±0.21	4.60±0.09	4.84±0.10
FINS (μIU/mL)
0 W	27.02±1.01	23.50±1.29	25.12±1.18	23.70±1.62	23.01±1.13
10 W	54.59±1.39^ab	55.31±1.06^ab	43.47 ± 1.31^a	45.98 ± 1.36^a	30.18±1.18
18 W	60.16 ± 2.52^abc	43.55±2.69	45.87±1.01	41.17±2.12	31.66±1.83
HOMA-IR
0 W	3.24±0.51	3.16±0.20	3.18±0.42	3.11±0.39	3.14±0.03
10 W	12.56±0.85^ab	12.64 ± 1.12^ab	8.32±0.08	8.37±1.02	6.52±1.96
18 W	13.36±1.06^abc	9.25±1.42	9.31±1.03	8.52±1.19	6.91±0.45

Data was shown as mean ± SEM. ^a𝑃<0.05 compared with the CF group; ^b𝑃<0.05 compared with the DIO-R/HF group; ^c𝑃<0.05 compared with their perspective CF intervention group. FPG: fasting serum glucose; FINS: fasting serum insulin; DIO: dietary induced obesity; DIO-R: dietary induced obesity resistant; CF: chow food; DIO/HF: DIO on HF; DIO/CF: DIO on CF; DIO-R/HF: DIO-R on HF; DIO-R/CF: DIO-R on CF.