A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice
Figure 3
Obese female mice have larger adipocytes and reduced prevalence of crown-like structures in gonadal adipose tissue when compared to weight-matched obese male mice. Male and female C57BL/6 mice were fed either a standard rodent chow or a high-fat diet (HFD) from 6 weeks of age until the HFD-fed group achieved a body weight of 45 g. At that time, both chow- and HFD-fed males (21 weeks old) or females (38 weeks old) were sacrificed and histological analysis was performed on gonadal adipose tissue. Representative H&E stains of gonadal adipose tissue from each of the four treatment groups are presented in panel (a). Sections were used to quantify the presence of crown-like structure (b) and to calculate average adipocyte area (c). Data are reported as mean ± SE; –8 per group; means with different superscripts differ by ; *; .
