Procalcific Phenotypic Drift of Circulating Progenitor Cells in Type 2 Diabetes with Coronary Artery Disease
Figure 2
Pro-calcific differentiation of cultured EPCs. (a) EPCs cultured from DM+CAD+ patients developed dense nodules highly suggestive of calcification, while EPCs cultured from DM+CAD− patients did not. The lower lane shows double Lectin/AcLDL immunofluorescence analysis of cultured EPCs. ((b) and (c)) Cultured EPCs and HUVECs express bone-related antigenic markers after challenging with LPS 100 nM for 7 days. * versus control experiment, set at 1.0.
