Insulin Resistance Promotes Early Atherosclerosis via Increased Proinflammatory Proteins and Oxidative Stress in Fructose-Fed ApoE-KO Mice

Figure 1

Morphometric analysis of the middle layer of aorta (a) and mesenteric arteries (b) from WT and ApoE-KO mice fed regular chow (Control diet) or high fructose diet (HF). ApoE-KO mice display a decreased lumen/media ratio in vessels walls from fructose-fed ApoE-KO mice. Results are expressed as means (𝑛=8) ± S.E.M **𝑃<0.001 versus ApoE control in aortic rings; *𝑃<0.05 versus WT, ^§𝑃<0.05 versus ApoE control in mesenteric arteries rings.

(a)

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