Insulin Resistance Promotes Early Atherosclerosis via Increased Proinflammatory Proteins and Oxidative Stress in Fructose-Fed ApoE-KO Mice

Figure 2

High fructose intake enhances atheroma development. (a) Representative of whole aorta artery and (b) representative of right carotid artery staining with Oil-red O. Extent of atherosclerosis quantified as percent of plaque area in ApoE-KO mice fed control diet and HF diet. (c) Cross-sections from the aortic sinus were stained with hematoxylin and eosin to quantify the lesion area. Results are expressed as means (𝑛=8) ± S.E.M *𝑃<0.05; **𝑃<0.01 versus control diet.

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