Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians
Table 2
Variants showing association (uncorrected P-value) with type 2 diabetes and obesity.
Trait
Gene
SNP
Allele (major/minor)
MAF (affected/unaffected)
OR (95% CI)
P
Type 2 diabetes (total study population: 1019 cases versus 1006 controls)†
MTHFR
rs1801133
C/T
0.18/0.21
0.78 (0.67–0.92)
0.003
Type 2 diabetes (Normal weight subjects: 290 cases versus 436 controls)†
MTHFR
rs1801133
C/T
0.18/0.21
0.62 (0.46–0.85)
0.002
MTHFR
rs9651118
C/T
0.26/0.25
1.31 (1.01–1.68)
0.04
CHDH
rs4563403
G/A
0.10/0.11
0.66 (0.45–0.95)
0.02
CBS
rs706208
T/C
0.41/0.39
1.30 (1.03–1.63)
0.03
MTHFD1L
rs1555179
C/T
0.26/0.23
1.36 (1.04–1.78)
0.03
Type 2 diabetes (Obese/over-weight subjects: 691cases versus 562 controls)†
MTHFD1
rs1076991
A/G
0.40/0.44
0.81 (0.69–0.95)
0.01
TCN2
rs1801198
G/C
0.42/0.44
0.85 (0.72–0.99)
0.04
Obesity (562 Obese/over-weight versus 436 normal weights)‡
CHDH
rs4563403
G/A
0.09/0.13
0.69 (0.52–0.92)
0.01
TCN2
rs1801198
G/C
0.46/0.41
1.24 (1.04–1.48)
0.02
MTR
rs16834521
T/C
0.31/0.35
0.82 (0.68–0.99)
0.04
†Analyses adjusted for sex, age, and BMI. ‡Analysis performed only in control subjects and adjusted for sex and age, MAF: minor allele frequency, OR: odds ratio, CI: confidence interval.
