Research Article
Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico
Table 3
Genotypic and allelic frequencies of polymorphisms in the CRP gene by study groups.
| | SNP | All
| Healthy
| T2D without obesity | Obesity
| T2D with obesity | P value | | n (%) | n (%) | n (%) | n (%) | n (%) |
| | rs1130864 | | | | | | | | CC | 108 (26.9) | 47 (36.2) | 25 (26.9) | 20 (18.9) | 16 (21.9) | 0.029a | | CT | 216 (53.7) | 68 (52.3) | 47 (50.5) | 61 (57.5) | 40 (54.8) | | TT | 78 (19.4) | 15 (11.5) | 21 (22.6) | 25 (23.6) | 17 (23.3) | | C | 432 (53.7) | 162 (62.3) | 97 (52.1) | 101 (47.6) | 72 (49.3) | | T | 372 (46.3) | 98 (37.7) | 89 (47.9) | 111 (52.4) | 74 (50.7) | | HWE: (P) | | 1.7 (0.20) | | | |
| | rs1205 | | | | | | | | GG | 127 (31.6) | 37 (28.5) | 31 (33.3) | 35 (33.0) | 24 (32.9) | 0.866a | | GA | 171 (42.5) | 55 (42.3) | 37 (39.8) | 45 (42.5) | 34 (46.6) | | AA | 104 (25.9) | 38 (29.2) | 25 (26.9) | 26 (24.5) | 15 (20.6) | | G | 425 (52.9) | 129 (49.6) | 99 (53.2) | 115 (54.3) | 82 (56.2) | | A | 379 (47.1) | 131 (50.4) | 87 (46.8) | 97 (45.8) | 64 (43.8) | | HWE: (P) | | 3.0 (0.08) | | | |
| | rs2794521 | | | | | | | | AA | 314 (78.1) | 111 (85.4) | 68 (73.1) | 81 (76.4) | 54 (74.0) | 0.281b | | AG | 79 (19.7) | 17 (13.1) | 22 (23.7) | 23 (21.7) | 17 (23.3) | | GG | 9 (2.2) | 2 (1.5) | 3 (3.2) | 2 (1.9) | 2 (2.7) | | A | 707 (87.9) | 239 (91.9) | 158 (85.0) | 185 (87.3) | 125 (85.6) | | G | 97 (12.1) | 21 (8.1) | 28 (15.0) | 27 (12.7) | 21 (14.4) | | HWE: (P) | | 1.9 (0.174) | | | |
| | rs3093062 | | | | | | | | GG | 378 (94.0) | 127 (97.7) | 86 (92.5) | 98 (92.5) | 67 (91.8) | 0.137b | | GA | 24 (6.0) | 3 (2.3) | 7 (7.5) | 8 (7.5) | 6 (8.2) | | G | 780 (97.0) | 257 (98.9) | 179 (96.2) | 204 (96.2) | 140 (95.9) | | A | 24 (3.0) | 3 (1.1) | 7 (3.8) | 8 (3.8) | 6 (4.1) | | HWE: (P) | | 0.02 (0.894) | | | |
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The data indicate n (%). HWE: Hardy-Weinberg equilibrium.
a test; bFisher's exact test.
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