Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico
Table 4
Effect of the SNPs on hsCRP levels or BMI.
SNP
CRP (mg/L)
Log CRP (mg/L)
BMI (kg/m2)
Log BMI (kg/m2)
GM (95%CI)
β (95%CI)a
P value
GM (95%CI)
β (95%CI)b
P valuec
rs1130864
CC
1.7 (1.4–2.1)
Reference
26.2 (25.3–27.1)
Reference
CT
2.3 (2.0–2.6)
0.2 (0.05, 0.4)
0.128
27.4 (26.7–28.1)
0.04 (−0.02, 0.1)
0.065
TT
2.9 (2.2–3.9)
0.4 (0.1, 0.7)
0.015
28.2 (26.8–29.7)
0.1 (0.01, 0.1)
0.016
P trend
0.001
0.012
CT + TT
2.4 (2.1–2.8)
0.2 (0.1, 0.6)
0.045
27.6 (27.0–28.3)
0.05 (0.01, 0.1)
0.024
rs1205
GG
2.5 (2.0–3.0)
Reference
27.5 (27.0–29.4)
Reference
GA
2.6 (2.2–3.0)
0.1 (−0.2, 0.3)
0.423
27.4 (26.6–28.2)
−0.01 (−0.1, 0.04)
0.871
AA
1.5 (1.2–1.9)
−0.4 (−0.7, −0.2)
0.002
26.6 (25.7–27.6)
−0.03 (−0.1, 0.02)
0.197
P trend
0.001
0.220
GA + AA
2.1 (1.8–2.4)
−0.1 (−0.3, −0.1)
0.334
27.1 (26.5–27.7)
−0.02 (−0.1, 0.02)
0.477
rs2794521
AA
2.1 (1.9–2.4)
Reference
27.0 (26.4–27.6)
Reference
AG
2.7 (2.1–3.4)
0.1 (−0.1, 0.4)
0.317
28.1 (26.8–29.4)
0.04 (−0.01, 0.1)
0.105
GG
2.1 (0.7–6.0)
−0.1 (−0.8, 0.4)
0.747
28.2 (24.2–32.9)
0.04 (−0.1, 0.2)
0.501
P trend
0.164
0.109
AG + GG
2.6 (2.1–3.3)
0.1 (−0.1, 0.3)
0.398
28.1 (26.9–29.4)
0.04 (−0.01, 0.08)
0.087
rs3093062
GG
2.1 (1.9–2.4)
Reference
27.1 (26.6–27.7)
Reference
GA
3.7 (2.4–5.9)
0.3 (−0.1, 0.8)
0.108
29.4 (26.6–32.3)
0.1 (−0.01, 0.2)
0.060
P trend
0.020
0.060
aModels adjusted by risk score of coronary heart disease, body mass index, and place of origin.
bModels adjusted by risk score of coronary heart disease and place of origin. GM: geometric mean.
cUncorrected P values.
