Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico
Table 5
Association of haplotypes in CRP gene with circulating levels of CRP and body mass index.
Haplotype
SNP
Log CRP (mg/L)
Log BMI (kg/m2)
rs1130864
rs1205
rs2794521
rs3093062
Frequency
β (95%CI)a
P value
β (95%CI)b
P value
1
C
A
A
G
0.2934
Ref
Ref
2
T
G
A
G
0.2818
0.3 (0.1, 0.5)
0.005
0.04 (0, 0.1)
0.059
3
C
G
A
G
0.1523
0.2 (−0.01, 0.5)
0.057
0.01 (−0.04, 0.06)
0.57
4
T
A
A
G
0.127
0.2 (−0.1, 0.4)
0.27
0.04 (−0.02, 0.1)
0.17
5
C
G
G
G
0.0403
0.1 (−0.4, 0.5)
0.72
−0.03 (−0.1, 0.1)
0.46
6
C
A
G
G
0.0389
0.1 (−0.3, 0.6)
0.59
0.07 (−0.03, 0.2)
0.16
7
T
G
G
G
0.0291
0.7 (0.2, 1.2)
0.01
0.2 (0.1, 0.3)
<0.001
8
C
G
A
A
0.0101
0.7 (−0.04–1.5)
0.063
0.2 (0, 0.3)
0.049
Rare
0.027
0.6 (0.1, 1.1)
0.015
0.1 (−0.1, 0.2)
0.29
aModels adjusted by risk score of coronary heart disease, body mass index, and place of origin.
bModels adjusted by risk score of coronary heart disease and place of origin.
cUncorrected P values.
