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Journal of Diabetes Research
Volume 2013 (2013), Article ID 103731, 9 pages
http://dx.doi.org/10.1155/2013/103731
Research Article

A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat

1Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
2Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
3Hoshino Laboratory Animals, Inc., Ibaraki 306-0606, Japan
4Animal Research Center, Tokyo Medical University, Tokyo 160-8402, Japan
5Japan SLC, Inc., Hamamatsu 431-1103, Japan
6Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
7The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan

Received 22 November 2012; Accepted 4 January 2013

Academic Editor: Takahisa Yamada

Copyright © 2013 Norihide Yokoi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Goto, M. Kakizaki, and N. Masaki, “Spontaneous diabetes produced by selective breeding of normal Wistar rats,” Proceedings of the Japan Academy, vol. 51, no. 1, pp. 80–85, 1975.
  2. K. Kawano, T. Hirashima, S. Mori, Y. Saitoh, M. Kurosumi, and T. Natori, “Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain,” Diabetes, vol. 41, no. 11, pp. 1422–1428, 1992. View at Scopus
  3. M. Shinohara, T. Masuyama, T. Shoda et al., “A new spontaneously diabetic non-obese torii rat strain with severe ocular complications,” International Journal of Experimental Diabetes Research, vol. 1, no. 2, pp. 89–100, 2000. View at Scopus
  4. T. Masuyama, Y. Katsuda, and M. Shinohara, “A novel model of obesity-related diabetes: introgression of the Leprfa allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats,” Experimental Animals, vol. 54, no. 1, pp. 13–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Ikeda, A. Shino, T. Matsuo, H. Iwatsuka, and Z. Suzuoki, “A new genetically obese-hyperglycemic rat (Wistar fatty),” Diabetes, vol. 30, no. 12, pp. 1045–1050, 1981. View at Scopus
  6. R. G. Peterson, W. N. Shaw, M. A. Neel, L. A. Little, and J. Eichberg, “Zucker diabetic fatty rat as a model for non-insulindependent diabetes mellitus,” ILAR News, vol. 32, no. 3, pp. 16–19, 1990.
  7. K. P. Hummel, M. M. Dickie, and D. L. Coleman, “Diabetes, a new mutation in the mouse,” Science, vol. 153, no. 3740, pp. 1127–1128, 1966. View at Scopus
  8. M. Nishimura, “Breeding of mice strains for diabetes mellitus,” Jikken Dobutsu, vol. 18, pp. 147–157, 1969.
  9. M. Shibata and B. Yasuda, “New experimental congenital diabetic mice (N.S.Y. mice),” Tohoku Journal of Experimental Medicine, vol. 130, no. 2, pp. 139–142, 1980. View at Scopus
  10. M. Bielschowsky and C. M. Goodall, “Origin of inbred NZ mouse strains,” Cancer Research, vol. 30, no. 3, pp. 834–836, 1970. View at Scopus
  11. J. H. Kim, A. Sen, C. S. Avery et al., “Genetic analysis of a new mouse model for non-insulin-dependent diabetes,” Genomics, vol. 74, no. 3, pp. 273–286, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Suzuki, S. Iizuka, M. Tabuchi et al., “A new mouse model of spontaneous diabetes derived from ddY strain,” Experimental Animals, vol. 48, no. 3, pp. 181–189, 1999. View at Scopus
  13. T. Akimoto, K. Nakama, Y. Katsuta et al., “Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Leprfa) rat,” Biochemical and Biophysical Research Communications, vol. 366, no. 2, pp. 556–562, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. L. M. Zucker and T. F. Zucker, “Fatty, a new mutation in the rat,” Journal of Heredity, vol. 52, no. 6, pp. 275–278, 1961. View at Scopus
  15. N. Yokoi, S. Hidaka, S. Tanabe, et al., “Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats,” Genes and Immunity, vol. 13, no. 2, pp. 139–145, 2012.
  16. U. Janssen, A. O. Phillips, and J. Floege, “Rodent models of nephropathy associated with type II diabetes,” Journal of Nephrology, vol. 12, no. 3, pp. 159–172, 1999.
  17. V. Brussee, G. Guo, Y. Dong et al., “Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model,” Diabetes, vol. 57, no. 6, pp. 1664–1673, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Dubern and K. Clement, “Leptin and leptin receptor-related monogenic obesity,” Biochimie, vol. 94, no. 10, pp. 2111–2115, 2012.
  19. J. Nizard, M. Dommergues, and K. Clement, “Pregnancy in a woman with a leptin-receptor mutation,” The New England Journal of Medicine, vol. 366, no. 11, pp. 1064–1065, 2012.
  20. I. Mazen, M. El-Gammal, M. Abdel-Hamid, I. S. Farooqi, and K. Amr, “Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity,” Molecular Genetics and Metabolism, vol. 102, no. 4, pp. 461–464, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. M. Chelich and E. S. Edmonds, “Copulatory behavior and reproductive capacity of the genetically obese female Zucker rat,” Physiology and Behavior, vol. 27, no. 2, pp. 331–335, 1981. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Kava, M. R. C. Greenwood, and P. R. Johnson, “Zucker (fa/fa) rat,” ILAR News, vol. 32, no. 3, pp. 4–8, 1990.