Research Article
A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat
Table 1
Characteristics of the ZDF and ZFDM strains.
| | ZDF | ZFDM |
| Origin | ZF colony at Eli Lilly Research Laboratories (Indianapolis, IN) | ZF colony at Tokyo Medical University (Tokyo, Japan) | Genetic control | Inbred | Outbred | Obesity* | Early onset (6–10 wk) | Early onset (6–12 wk) | Diabetes* | Young-age onset (8–12 wk) | Young- to middle-age onset (10–20 wk) | Special diet | Purina 5008 | Not needed | Breeding | ♀ + × ♂ + | ♀ + × ♂ |
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*Characteristics of fa/fa male rats in the ZDF and ZFDM strains.
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