Research Article

The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice

Figure 1

Immunohistochemistry of NADPH oxidase p47phox and malondialdehyde (MDA) in the kidneys of the control (C) and streptozotocin-induced diabetic (DM) in wild and adrenomedullin gene knockout (AMKO) mice. Immunoreactivity for p47phox and its product MDA was stronger in the glomeruli and distal tubules, including the macula densa (arrowhead), in the DM mice compared with that observed in the controls in both wild and AMKO mice, and was stronger in the AMKO-DM mice than in the wild-DM. The bar indicates 50  m.
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