Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy
Figure 1
Immunostaining for PTHrP in the kidney of patients with diabetic nephropathy. PTHrP was detected by using a goat α-PTHrP antibody (Santa Cruz Biotechnology) in kidney tissue sections from patients with clinical and histological diagnosis of DN. (a) Section from normal kidney showing PTHrP immunostaining restricted to the epithelial cells cytoplasm of convoluted renal tubules. (b, c) Kidney samples from two diabetic patients with different degree of DN: one patient with moderate (b) or more severe (c) diabetic glomerulosclerosis. PTHrP labelling was present in both the glomeruli and the tubuloepithelial cells. Original magnifications ×300.
