Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ

Table 2

Summary comparison of the 3 models.

	BKS-db/db	NONcNZO10/LtJ	TALLYHO/JngJ
Obesity	Monogenic, morbid	Polygenic, moderate	Polygenic, moderate
Diabetes	Juvenile onset	Maturity onset	Maturity onset
Leptin resistance	Central, total	Peripheral, moderate	Peripheral, moderate
Insulin resistance	Severe	Moderate	Moderate
Sex bias	None	Males	Males
Littermate controls	Yes	No	No
Fertile	No	Yes	Yes