The effects of adipokines on hepatic glucose metabolism and insulin signalling. Both of adiponectin (APN) and leptin can decrease hepatic gluconeogenesis. Resistin (REN) can increase hepatic gluconeogenesis and glycogenolysis. Moreover, interleukin-6 (IL-6) can decrease glycogen synthesis, and tumor necrosis factor (TNF-) can decrease glucose uptake in liver. Both of them can block hepatic insulin signalling by interfection of insulin receptor signalling and insulin signal transduction.
