Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 14

The fructose levels in the sciatic nerves at 40 weeks. The fructose levels in the sciatic nerves in the untreated SDT rats are significantly higher in the SD rats. ^∗∗𝑃<0.01, Student’s 𝑡-test. The fructose levels in the sciatic nerves treated with all doses of ranirestat are significantly lower than in the untreated SDT rats. ^†𝑃<0.05 and ^‡𝑃<0.01, Dunnett type joint-ranking test. Epalrestat does not affect the reduced fructose levels. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epal: epalrestat.