Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 15

Pathology (hematoxylin, original magnification 4x) at 40 weeks. In an untreated eye (left), the lens has a sclerotic nucleus floating in liquefied cortex and vacuolation and disintegration of cortex fibers. In the epalrestat-treated eye (middle), the findings are virtually the same as in the untreated eye. In the ranirestat-treated eyes (right), the eye has an almost normal lens and retina.