Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 6

The MNCV levels in the sciatic nerves at 40 weeks. The MNCV levels in the sciatic nerves of the untreated SDT rats at 40 weeks are significantly lower than those of the SD rats. ^∗∗𝑃<0.01, Student’s 𝑡-test. The MNCV levels in the sciatic nerves of the SDT rats treated with ranirestat and those treated with epalrestat are significantly higher than those of the untreated SDT rats. ^‡𝑃<0.01, Dunnett type mean rank test and ^†𝑃<0.05, Student’s 𝑡-test. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epa: epalrestat.