Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 7

The sorbitol levels in the lenses at 15 weeks. Although there seems to be a dose-dependent decrease in the sorbitol levels in the lenses with administration of ranirestat, the sorbitol levels in the untreated lenses and in the lenses treated with epalrestat are very low. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epa: epalrestat.