Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

<table>The sorbitol levels in the lenses at 40 weeks. Although there seems to be a dose-dependent decrease in the sorbitol levels in the lenses with administration of ranirestat, the sorbitol levels in the untreated lenses and in those treated with epalrestat are very low. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epa: epalrestat. </table>

Journal of Diabetes Research

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Figure 8

Figure 8: Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats 

Figure 8 | Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats 