Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia: Role of Hypoxia-Inducible Factor-1α
Figure 8
AGE increases VEGF mRNA expression in a HIF-1α-dependent manner. Cells were preincubated with HIF-1α inhibitor YC-1 or transfected with HIF-1α siRNA or control siRNA (scramble) as indicated in Section 2. Then they were incubated with albumin or AGE, and VEGF mRNA expression was quantified by Q-RT-PCR. Bars are the mean ± SD of 3 different experiments. * versus albumin; + versus AGE.
