In Vivo Efficacy of HD0471953: A Novel GPR119 Agonist for the Treatment of Type 2 Diabetes Mellitus

Figure 3

Effect of chronic treatment within diabetic db/db mice. A 10 mg/kg dose of HD0471953 or vehicle was administered twice daily to diabetic db/db mice (𝑛=7) for 4 weeks. (a) The effect on plasma glucose levels in db/db mice during an OGTT. (b) The area under the plasma glucose concentration time curve for 2 h (AUC0-2 h) in an OGTT. (c) Plasma HDL, (d) plasma LDL, (e) plasma CHOL, (f) plasma triglyceride (TG), (g) initial body weight and final body weight, and (h) fasting insulin level. Data are presented as the mean ± SE. ^∗𝑃<0.05 versus vehicle group.

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