Research Article

RU28318, an Aldosterone Antagonist, in Combination with an ACE Inhibitor and Angiotensin Receptor Blocker Attenuates Cardiac Dysfunction in Diabetes

Figure 3

The effect of drugs given before ischemia on % recovery in cardiac function versus reperfusion time for (a) , (b) LVEDP, (c) , (d) , and (e) CF in diabetic hearts. RU: RU28318; Capt: Captopril; Los: Losartan; Triple: RU28318 + Captopril + Losartan; : left ventricular developed pressure; LVEDP: left ventricular end-diastolic pressure; : positive derivative of pressure; : negative derivative of pressure; CF: coronary flow; % : % recovery: (reperfusion/baseline) × 100.
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(a)
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(b)
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(c)
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(d)
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(e)