RU28318, an Aldosterone Antagonist, in Combination with an ACE Inhibitor and Angiotensin Receptor Blocker Attenuates Cardiac Dysfunction in Diabetes
Figure 8
A comparison of the % change in negative derivative of pressure () in control and diabetic hearts following acute treatment with various drug regimens. Drugs were given to control hearts during perfusion (a) or reperfusion (b) and to diabetic hearts during perfusion (c) or reperfusion (d). The percent change in parameter is calculated relative to the % recovery seen in the respective nondiabetic or diabetic controls. RUL: RU28318; Capt: Captopril; Los: Losartan; Triple: RU28318 + Captopril + Losartan.
