Maternal Rat Diabetes Mellitus Deleteriously Affects Insulin Sensitivity and Beta-Cell Function in the Offspring

Figure 6

Photomicrograph of pancreas section of diabetic rat offspring after two weeks of birth showing severe degenerative changes. Many necrotic foci (nc) vacuolations (v) are noticed in the islets (IL); the number of beta-cells (b) is reduced and the hypertrophied ones are degenerating. Alpha-cells, delta-cells, and pancreatic acini (pa) are indicated by symbols a, d, and pa, respectively, (×400).