Maternal Rat Diabetes Mellitus Deleteriously Affects Insulin Sensitivity and Beta-Cell Function in the Offspring

Table 2

Serum insulin concentration (μU/mL) of offspring of normal and diabetic dams at different experimental periods.

(a) One-way ANOVA

Groups	Periods
	0 week	1 week	2 weeks
offspring of normal dams	1.75±0^d; (𝑛=6)	2.9±0.001^b; (𝑛=6)	3.43±0.09^a; (𝑛=6)
offspring of diabetic dams	2.4±0.06^c; (𝑛=6)	1.75±0.02^d; (𝑛=6)	1.55±0.02^e; (𝑛=6)
% Difference	+37.1%	−39.7%	−54.8%
𝐹-probability	<0.001	<0.001	<0.001
LSD at 5% level	0.14	0.14	0.14
LSD at 1% level	0.19	0.19	0.19

(b) Two-way ANOVA

Effect of time	Effect of diabetes	Time-diabetes interaction
𝑃<0.001	𝑃<0.001	𝑃<0.001

Data are given as mean ± SE; means with the same superscript are not significantly different.
0 week = at birth; 1 week = end of the 1st postnatal week; 2 weeks = end of the 2nd postnatal week; number of observations; % difference: difference between offspring of normal and diabetic dams.