Maternal Rat Diabetes Mellitus Deleteriously Affects Insulin Sensitivity and Beta-Cell Function in the Offspring

Table 4

HOMA-IS of offspring of normal and diabetic dams at different experimental periods.

(a) One-way ANOVA

Groups	Periods
	0 week	1 week	2 weeks
offspring of normal dams	151.3±11.8^a; (𝑛=6)	54.2±3.1^a; (𝑛=6)	47.2±4.3^a; (𝑛=6)
offspring of diabetic dams	47.1±1.9^b; (𝑛=6)	42±0.5^b; (𝑛=6)	41.1±0.8^a; (𝑛=6)
% Difference	−68.9%	−22.5%	−12.9%
𝐹-probability	<0.001	<0.01	>0.05
LSD at 5% level	26.8	7.03	—
LSD at 1% level	38.1	10	—

(b) Two-way ANOVA

Effect of time	Effect of diabetes	Time-diabetes interaction
𝑃<0.001	𝑃<0.001	𝑃<0.001

Data are given as mean ± SE; means with the same superscript are not significantly different.
0 week = at birth; 1 week = end of the 1st postnatal week; 2 weeks = end of the 2nd postnatal week; number of observations; % difference: difference offspring of normal and diabetic dams; HOMA-IS: homeostasis model assessment for insulin sensitivity.