Maternal Rat Diabetes Mellitus Deleteriously Affects Insulin Sensitivity and Beta-Cell Function in the Offspring

Table 5

HO1MA 𝛽-cell function of offspring of normal and diabetic dams at different experimental periods.

(a) One-way ANOVA

Groups	Periods
	0 week	1 week	2 weeks
Normal offspring	1.03±0.08^a; (𝑛=6)	0.97±0.06^a; (𝑛=6)	1.18±0.1^a; (𝑛=6)
Diabetic offspring	0.56±0.02^b; (𝑛=6)	0.24±0.01^b; (𝑛=6)	0.22±0.004^b; (𝑛=6)
% Difference	−45.6%	−75.3%	−81.4%
𝐹-probability	<0.001	<0.001	<0.001
LSD at 5% level	0.21	0.14	0.25
LSD at 1% level	0.29	0.19	0.36

(b) Two-way ANOVA

Effect of time	Effect of diabetes	Time-diabetes interaction
𝑃<0.05	𝑃<0.001	𝑃<0.01

Data are given as mean ± SE; means with the same superscript are not significantly different.
0 week = at birth; 1 week = end of the 1st postnatal week; 2 weeks = end of the 2nd postnatal week; number of observations; % difference: difference between offspring of normal and diabetic dams; HOMA-beta-cell function: homeostasis model assessment for 𝛽-cell function.