Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats

Figure 2

Oxidative DNA damage in retinal vessels derived from intravitreally MGO-injected rat eyes. The retinal tissues were stained with 8-OHdG, which is a marker for oxidative DNA damage (red). Representative photomicrographs of the retinal vasculature from a saline-injected eye (a), a MGO-injected eye (b), and an EP-treated eye (c). (d) Quantitative analysis of the 8-OHdG-positive cells. The data are expressed as the means ± SE. (𝑛=8). ^∗𝑃<0.01 versus the control group, ^#𝑃<0.01 versus the MGO-injected group.

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